I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.Spacebar Clicker Performance by US States State ![]() I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). ![]() I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as. The qMAP-PD study has full NHS ethical approval (Fulham Research Ethics Committee, 18/LO/1229).Īll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Ethics approval was granted by the PREDICT-PD study was approved by Central London Research Committee 3 (reference number 10/H0716/85). The authors confirm that all participants gave verbal and written consent for this work. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this work is consistent with those guidelines. The details of the IRB/oversight body that provided approval or exemption for the research described are given below: I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. ![]() The Wellcome Centre for Human Neuroimaging is supported by core funding from the Wellcome Trust (203147/Z/16/Z). He also reports grants and/or research support from the Frances and Renee Hock Fund.ĪS is supported by the NIHR UCL/H Biomedical Research Centre.ĬL is supported by an MRC Clinician Scientist award (MR/R006504/1). No other disclosures were reported.ĪL is funded by the Reta Lila Weston Institute of Neurological Studies, University College London, Institute of Neurology and reports consultancies/honoraria from Britannia Pharmaceuticals and BIAL Portela. The Preventive Neurology Unit is funded by the Barts Charity.ĪJN reports additional grants from Parkinson’s UK, Virginia Keiley benefaction, Aligning Science Across Parkinson's and Michael J Fox Foundation, and personal fees/honoraria from Britannia, BIAL, AbbVie, Global Kinetics Corporation, Profile, Biogen, Roche and UCB, outside of the submitted work.ĬS is funded by Fundacion Alfonso Martin Escudero, Spain. The authors have declared no competing interest. Patients with anosmia also showed detectable differences in motor performance compared with controls which may be important indication of the prodromal phase of PD. ![]() Mean tap velocity appeared to be the best parameter to differentiate patients with PD from controls. Conclusions We present a new simple method to detect early motor dysfunction in PD.
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